My cat Spunky had a terrible time with car sickness. When we traveled to Cape Cod(from NJ), the last meal the cats ate was the evening meal on Friday(we left Saturday @ 0430). About one hour before leaving, I would give Spunky Tabacum 30C, a homeopathic remedy. It helped. Also used ginger. I found it was best NOT to put Spunky in the carrier. I would put a thick towel on my lap, and let him sleep/sit there. I also had a litter box handy for him to use. I hope this helps...