My vet said it is best to start the Melatonin early so this would probably be the ideal time for Spurr to start it if he is adrenal. So far I've not noticed any difference in Sebastian, but it's only been a week. He seems more "lively" when he's up, could be my imagination, but there is no hair growth yet. I'm trying to be patient as she said it would take 4-6 weeks to see any difference. Seriously considering the sweater option for him as it was only 7oC here this morning and the furnace came on.