Poor Zeke!! I hope he gets feeling better. Have you tried any venison formula dog foods? Nebo had problems (diarrhea) with other dog foods but he does great on anything venison based.

I believe lupus is a skin condition in dogs and it does affect the nose. There's a collie that comes in our shop that has it and his nose is very crusty/red as are his paw pads. That's all I know about it, maybe you should get Zeke tested?