I believe in vaccines. Since we deal with ferals I've seen the difference in the ones that have received them vs. the ones that haven't. The vaccines seem to help them survive much better. If they're strictly indoors than that's a different issue. My only argument there is, ours are indoors with the access of some outdoor life in the cat run. This gives them the chance that other outside cats could bring something to them, so we vaccinate. If yours are exposed to open doors/windows and other cats come along, than I would vaccinate. This is just my opinion for whatever that's worth. It's like vaccinating children against diseases. I feel, especially in the early years, they're necessary.