We have been taking 8 cats to Cape Cod for about 10 years. We do not feed them until they are at the rented cottage on the Cape. I have always offered some pieces of dry food as " treats," some eat them others do not. I have never had to sedate any of them. Once the initial meowing stops because they have realized they are not going to the vet, they quiet down and go to sleep. I have a litter box handy, in case anyone has to go(usually no).
We have also moved twice with the cats. I will bring them into the house after the movers are gone,door and windows closed so no one can escape in the confusion(all are indoor cats).
When moving, talk to them, tell them what is going to happen and why you are going to do what you will do. I have also given them the Bach Flower Remedy WALNUT. It is to help with changes, I think it did help. GOOD LUCK!!
PS: It is a good idea to get them use to the car with the short trips. Do not underestimate your cats, they may surprise you!!!