If you're talking about the initial price you pay a breeder I honestly don't think there is a most expensive breed, Bulldogs can run pretty high on average but so do many, many other breeds. The price depends on what each individual breeder wants to sell the puppies for. The average price for my 3 favourite breeds (Tollers, Groenendaels & Rotties) is between $1000 & $2500, there are some under and over those prices of course but that's the average. I've also seen breeders who want $4000+ and personally, I think that's absolutely insane.....
If you're talking about vet bills, I'd have to say generally speaking, Great Danes and other similar giant breeds would be the most expensive due to their short life span and health issues that come with these breeds. Small dogs can be really expensive as well because some owners don't brush their teeth often enough and small dogs are known for dental issues which can cost a lot to fix if you let their teeth get to s certain point, the same goes far all sizes of dogs but smaller ones I've found, seem to have the most problems.
Obviously, all of what I've said is just my opinion......
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