I use the straddle-from-the-rear approach - cat between legs, hold him/her at the chest, cradling the head. Gently open the cat's mouth, pop the pill down the throat, hold the mouth shut and then kiss the nose/mouth area while stroking the throat. Works almost every time, although Mishi has gotten good at quickly flicking it out with his tongue; I've gotten equally good at catching him doing this. We just finished THREE MONTHS of Baytril once a day so I've gotten the method down pat.