Yes, we've left our kitties home alone for several days. Our neighbor or my sister come by every day and feed and water them, plus sit for a while and cuddle. My neighbors will rent a movie and watch it here so that the kitties will cuddle on the couch for a while. And sometimes they leave the radio on real low so that the kitties hear music and voices and aren't so lonely. Our kitties have always done well but are always happy when we return.