My Bella also had Lyme disease a few years ago. It was before I had started her on Frontline and before receiving the vaccine. The first thing I noticed was a limp that began abruptly one morning. I thought she sprained something while running outside. She had none of the other symptoms that you mentioned. The vet tested her and she came up positive for Lyme's. It is treatable thankfully when caught early. Fingers crossed and lots of Get Well Wishes for Sally!!