How old is your dog and what breed is she?

I would not recommend Knuckle Bones, for very voracious chewers that haven't been exposed to them. There is a risk that she'll crack a tooth, especially back molars.... try Pork Necks or Turkey necks, or long marrow bones. If you do choose to try Knuckle Bones with her, make sure they're raw/frozen, boil them for a few seconds in hot water before feeding, and supervise her while she's chewing.