Angel did come around and let me play with her some last night. I gave her the medicine this morning just before leaving for work, and she went into hiding right after that again. I am home from work for the afternoon and still haven't seen her out and about. She will usually come out from where-ever she is when she hears me come home. I guess we'll keep working on reassuring her, and trying to associate positive things with it after giving it to her. Thanks for all of your comments and support. I absolutely HATE doing something like this to her that she doesn't understand, and that leads to some mistrust. We've never had to do this before.....