We used to take Kuhio to our cabin in the mountains. She would cry a few times and then quiet down. Her worst problem was getting car sick from all the curves.

Halo cried the entire way (2 hours) the first time we took her. The next time she quieted down and enjoyed the ride more.

My advice is not to give her any sedatives but to just let her cry as long as she needs while you reassure her. It could make for a long trip, but maybe having Maya with her will calm her down.