What I do with the brats that I can medicate is always give medication in the bathroom. That makes them feel safe in other parts of the house. Immediately after giving meds we have playtime with the cat charmer, shoe string, whatever they like to do. When Pete, Pepper, and Pervy were younger we had them on meds for awhile and I would still have to catch them but they immediately ran to daddy's chair afterwards because they new play time was coming. I try to always to that with my scaredy cats. I guess it lets them know that something good is coming after the nasty stuff! I don't know if that is any help but you might try it because after play time mine acted very normal and seemed to forget the bad part.

It's awful when they are upset with you isn't it? Especially when they act afraid. It breaks your heart.