About 2 years ago I would have said no large or even medium breeds. Harley is the biggest dog I ever owned and he weighs 23 lbs. After I adopted him and saw that there are so many large dogs that need homes I changed my mind. Now any breed or mix is fair game for me. We adopted Harley based on a lot of things, but size was a major one because I live with my parents and I have to respect their wishes. Plus we already had Sylvia and we worried a large dog could hurt her (my dad is REALLY protective of her).