To know what to do. I am having a similar situation with my new arrival Squeekers. He doesnt bite too much, but everytime I pick him up or try to love on him, he smacks at me and squirms to get away. All of my other kittens when they were little, were so sweet and loving, and he can be so mean sometimes. I understand that maybe I should not pressure him to cuddle, but I do not want him to grow up to be a mean cat. I dont know what to do either. Us meowmies have alot to deal with, eh? Good luck with your situation, and no i do not think it has anything to do with locking her up. I also locked up all of my other kittens when they were small to be safe, and they are perfectly sweet and loving. I hope all gets better, for you and your other furbabies.