I believe female spaying may cost more, b/c there is more to the surgery. Dale hasn't been neutered yet, b/c we were contemplating showing him, but we aren't going to, so I called the vet to see what the cost was to neuter him. We have only gone to this vet a couple of times (we are new to the area), so i am not "hooked" on them,...anyway, they quoted $252!! I thought that was a bit high! So, i called another vet in the area, that i hear is good, and they quoted $165, which is more like it! I think we will be switching vets...i think their prices are crazy high on everything! ANyway, just curious what it was to neuter your dog. Dale is a large breed, so size should be noted, since that can effect the price....