When we moved up here, my parents kept Mimi for me for a month or so because Helen and I were forced to live in a hotel until our house became available. For their peace of mind and mine, we asked their vet to give her a tranquilizer before they drove her up. She was pitiful and woozy as she awoke, but she traveled safely and readjusted in no time.

I would talk with your vet about it. I'm sure that he/she will have some good suggestions for you.