I agree...weekend isn't so bad when you have multiple cats.
The max I have left my two alone is four days...and again my mom coming in and spending some quality time with them.

Be prepared even with visitors stopping by with them, to have them keep you up that first night. Mine act as though they have been deserted for years by the time I get home on a Sunday night after leaving Friday night.
They spend the night fighting to sleep on my back, head, anywhere they can snuggle up to make sure I will be there when they wake up.