I'm sure they will be ok for one night. T & P used to be home...well, not all the time...but quite often on the weekends once I moved to Chicago and went home to visit my parents. I would usually leave Friday night after work, so they were alone two nights, and they were just fine. Every now and then I'd come home to pillows from the couch on the floor, or plants knocked over, or other evidence of the general chaos that must have occured over the weekend, but the kitties were just fine - and real happy to see me.