It once was "carved in stone", that all orange cats had to be male (no exception), and all calico cats had to be female (no exception there either). This was even held as gospel in the scientific world, as I will attest to this from when I worked in the Microbiology Dept at the Univ of DE back in the 70's. The PhD's that I worked with did genetic research, and they swore that it was an extreme rarity and mutation for an orange cat to be female. Just goes to show you that even the brainiacs can be proven wrong!