I guess I'm one of the fortunate folks that has never had any of my fur kids have any reaction to any vaccines - and I've been a Mom to many fur kids for 40+ years. I go to a wonderful vet and abide by what she feels is necessary for the good health of my kids.
My only problems occured when there were no vaccines. I lost my very first dog to distemper, and years later I lost two cats also. I had an indoor only cat that had no shots and then adopted a "healthy" kitten from the local SPCA. Three days later it was dead - I called the SPCA about it and was told that they just had to put down their entire cat population due to distemper - yet they never called me and alerted me to this. Of course the infected kitten passed it along to the cat I already had, and dispite efforts of a vet, I lost him also.
I will never put myself or any animal thru anything like that again - they get puppy/kitty shots, boosters every year, and rabies every 3 years.