I think they get a 3-1 like puppies and then it is yearly for rabies(at least here in Florida).

The fat thing, well just limit treats and be sure to give them as much free times out of their habitat as possible. My ferret use to like the cat toys with the little pole with the string and fuzzy toys at the end. She would chase that all over the house as long as someone moved it. If you are limited to home much your ferrets can be out try picking a room that you can put up a baby gate in the doorway. We have an extremely large masterbath so we took a baby gate and put plexi-glass on one side so she could not climb the gate or get her head stuck in the wholes. This way if I knew I was going to be gone all day I would just put the gate up and leave her cage door open in there with all her food and toys and she would play by herself.

I never really gave her treats. I know she liked the ferret-vit and cat hairball stuff. I actually taught her to sit and stand on her hind legs by putting a little on my finger and then letting her lick it off.

For the nails we just used regular people nail clippers. Hope this helps some.

I am sure there are many others on here that can give better advise or add to it. Here is another site that is pretty informative and will also answer questions. www.craftycreatures.com