Thanks everyone,
He has been off the meds for a day and a half now, though still in a funk so tomorrow he is going back to the vet as suggested. In the mean time he is holding the water he is given via the eyedropper. Still doesn't want anything to do with the water dish or soft food though.

Will post what the vet has to say.

Thanks for responding, good to get others opinions / ideas in these cases.