I have to agree with you that it's too early to give up on poor Pyka. It must be frustrating to try a medication only to see side effects. This is just a thought, is there a veterinary college anywhere near you or your mom? My concern is Pyka's ongoing problems with side effects from the meds that have been tried. The reason I mention this is because a co-worker was having problems with her cat that continued in spite of numerous visits to the vet. She took Callie to the veterinary college at the U of Penn where they finally figured things out. Prayers that Pyka will be feeling better very soon. Please keep us updated?