I'm no help on this subject because we dont leave our gang of 4 alone for even 1 night.
Having no immediate family near by nor close enough friends that I would feel comfortable with having them stay in our house or stopping by couple times a day would not work for us. I would worry and be miserable and thats not a vacation. LOL
One of us (myself or hubby) is with the kids when the other is going to be gone if it's a day or for a few days.

I've watch others pets for neighbors at old apartment complex. 1 household did real well while they were gone. Howver, the other household the cats ate very little, barfed allot and cried until their owners got home.