I don't think the wires will be a problem at first, but once the kittens are up and about they might become a problem. More than one kitten has been known to chew on wires. Is it possible that when no one is using the computer that it's unplugged and the wires put on top of the desk?

The only thing is, if you really want her to use that room, you may have to close her in it. Most times mama cats have different ideas about where is a good place to have their babies than what we think, so if she has access to the basement, she may just have them down there someplace. I think it's perfectly fine for her to be climbing stairs when she's pregnant, the only thing I would wonder about is once she has the babies, for the first few days she is not going to want to go far from them, so if the room is - say - on the second floor and the litterbox is in the basement, that might be a little further than she wants to go with new babies.

Other than that, everything sounds good! Good luck!