It is never an easy thing to do, but I have found the best way (for me), is to kneel on the floor with knees spread, grab cat and back them into the V. Left arm around cat and grabbing mouth, quickly coax mouth open using thumb and index finger with head slightly tilted back, toss pill in, shut mouth and massage throat and if necessary blow on nose if they haven't swallowed. Sometimes they trick me and I have to retrieve the slimy pill and try again, but this usually works pretty good. I prefer liquids too, but Rusty somehow manages to hold it in his mouth than spit it back at me.