To prepare for our drive from Chicago to LA I would take Edwina on short car trips so she begin to associate the car with something other than the vet. I also had them in the harnesses the whole trip....in case I needed to catch them (or drag them out from something...)

Eddie rode in his cage but with the door open and his head hanging out... Edwina sat on her car seat....looking out the window or sleeping. Occasionally she would sit in my lap.

They had food water and litter box but waited until we were in the hotel at night.

Here's the album of their trip.... Road Trip