OTIS AND MILO without a doubt! For those of you who haven't seen it, it's a great little story about a cute little orange kitten named Milo (you just know he stole my heart) and a precious little pug named Otis. It is an adventure that starts out with little Milo climbing into a box by the river (you know kitties and their curiosity) and it takes him on an adventure down the river with Otis following in hot pursuit!

Second choice would be "As Good As It Gets" with Jack Nicholson and the cute little Brussels Griffin!!