How much RAM did it have to start? I ask, because unless they are running an application that will use the extra RAM, adding more won't help, speed wise, much.
What apps, other than iTunes fail to run?
Try turning UAC off and see if that helps. UAC in Vista is awful and can cause many 3rd party TSR/Service based apps to not work correctly.
What AV software are they running? Are you sure there is only ONE AV software installed? We had a client install 3 different AV programs on his laptop. He thought it would make him more secure. LOL
As for DD... Just set it up in the scheduler. Have it kick off at like 1am on a certain day of the week and ask the user to just leave the computer on that night. Windows 7 gives even more options on this front.
"Unlike most of you, I am not a nut."
- Homer Simpson
"If the enemy opens the door, you must race in."
- Sun Tzu - Art of War
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