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Rather than jump right to medication, perhaps a special collar sprayed with Feliway is the way to go for Pearl while she gets used to the newcomers. My Diego is on prozac but there are times when he needs a little reinforcement and calming down still. That's when I break out his ever-so-cool black breakaway collar and give it a good spray with Feliway. Doesn't take long after its on before he is a very nice boy again and Miss Cali is safe.
Sorry to hear that the harmony is broken for a few of them.
I don't have a lot of disharmony. Sam does get jealous and will pick on Emily because she's so small, so he can be aggressive. Even as the largest at 17 pounds, Emily is the only one he can punk out.
Spunky annoys the other cats but really isn't aggressive. At 9 pounds he can send even Sam running. A water bottle gets my point across.
I hope you don't have to re-home Pearl. I had to re-hone Bertie because she growled at everyone constantly. WE have a sort of Peace now.
Good luck!