My sydney has had hyperthyroidism for over a year and a half. My vet has her one one pill 2x a day to keep her levels in check. It took us some time to get the dosage right, so you have to be patient. Sydney has days where she doing well and days were she acts like she is not doing as well. We have managed to get her weight from 6lbs 5 ounces to 10lbs 4 ounces (we are SUPER happy about this!). She has been on the medication for about a year and a half and her monthly kidney values have stayed within normal range. I guess my point is she has been doing well despite the diagnosis - so I would keep my hope up! Good luck! :love::love::love: