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Even the smallest dwarf rabbit can pose a physical danger to a guinea pig, especially if space is limited. Rabbits often kick or stomp with their powerful hind feet when they are expressing their emotions. Whether a rabbit is jumping for joy or thumping out of annoyance, a guinea pig stands a good chance of getting hurt. This is not as uncommon as you might think. Rescuers and other concerned animal welfarists often encounter guinea pigs whose legs have been broken after being caged in a pet store with a rabbit. Such injuries often require surgery and a lifetime regimen of anti-inflammatory medication.
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