Decisicion time - Fister!

[Randi]

It seems that Fister has problems peeing again. Just now, he was sitting in his litterbox for about 15 min. - but nothing!

It's less than 2 months ago he was in hospital for the same problem, (second time) and they said, that if the diet food can't keep it down, he has to have his penis cut off because of the long urinary tract male cats have. Fister has been on Hill's Science Diet prescription for UTI for quite a long time, which should help prevent recurrances of UTI and crystal formation, but it doesn't seem to be enough.

So we have to make a decision. Will give our vet a call now! It's thursday, so we better attend to this NOW! Our vet is closed weekends.

We have of course been thinking about whether other things could cause it and I have a feeling that lack of exercise could be the reason, because he hasn't been much out lately.

I'd like to ask if any of you have male cats who is indoor/outdoor cats with this problem?

Will let you know later what is happening! Please, keep your fingers crossed!

[sasvermont]

I would ask another Vet. I know that may say silly. I would also do a search on the Web for answers.

I know that cranberry juice is often given to humans to deter UTI infections and they come in tablets too.

If I were you, I would try to clear the infection one more time, then really try to get more water into him, lots of exercise and a strick strick diet of special food.

Cutting off his penis sounds so drastic to me. I don't know what it entails, but it just sounds awful.

Gosh. Whatever you two decide will be fine, I am sure, but gosh, what a decision to make!

Is there a Vet School somewhere nearby? Can you contact them?

Keep us posted.

[Randi]

We're waiting for the vet to call back. When we mentioned to our vet what the vet had said in the hospital last time, he also thought it sounded a bit drastic, but if we have to get him flushed through every 2 months and still keep him on the diet food, it's unbearable. If he has the operation, he won't ever have the problem again - and he may even be able to get his favourite treats again. Ohh, it's so hard to decide! Wish I knew more about it! I have been looking for websites about this and know that it can get quite serious very quickly if not treated, but the actual operation I don't know much about.

Will report back later!

[sasvermont]

Randi, I guess my concern would be the impact on his ability to control the urine. My guess is that they are removing any wall or barrier that my build up blockage. I got this from the net. Hope it helps you understand.

Lower Urinary Tract Disorders of the Cat
Katherine James -- April, 1998
Lecture 7
Terminology
The signs of lower urinary tract disease in the cat are hematuria, stranguria and pollakiuria. Several different conditions of the feline lower tract can result in theses signs. In many cases, no clearly defined cause is found. For many years, these cats were classified as having “feline urologic syndrome” (FUS). This term has now fallen out of favor because clinicians tended to equate feline lower urinary tract signs with FUS, in part because of how common the syndrome is in young cats. However, many disease conditions cause lower urinary tract signs and a diagnostic evaluation is warranted. Thus, the poorly understood syndrome known as FUS has been renamed as idiopathic feline lower urinary tract disease (IFLUTD). There is an inflammatory bladder disease in humans termed interstitial cystitis (IC). Its cause is similarly unknown. There are similarities between IFLUTD and IC. Thus, some people may refer to IFLUTD as IC. This is probably premature until more evidence is available to substantiate that these conditions are in fact the same. It is appropriate to refer to IFLUTD as “idiopathic sterile cystitis.”

Clinical signs of lower urinary tract disease include hematuria, dysuria, pollakiuria, stranguria, and/or partial or complete urinary tract obstruction. Some cats with lower urinary tract disease may urinate outside the litterbox, although this sign is not specific for lower urinary tract disease and is also seen with behavioral disorders. Veterinary urologists also frequently divide IFLUTD into obstructive and non-obstructive disease. This is useful as the management strategies and outcomes are often significantly different in the short term.

Causes of Feline Lower Urinary Tract Disease
Bacterial Infections
Bacterial urinary tract infections in cats are uncommon. They account for approximately 1-3% of cases of feline lower urinary tract disease (FLUTD). Feline bacterial urinary tract infections (UTIs) usually result from compromised local defenses and, therefore, are more likely to be secondary to other disorders, rather than a primary problem. The high osmolarity and high concentrations of urea and organic acids in feline urine inhibit bacterial growth. Bacterial UTIs are relatively common in cats after placement of urinary catheters, or in cats with perineal urethrostomies. This suggests that the urethra itself is an important defense against bacterial UTI in the cat.
Diagnosis of bacterial UTI in a cat should prompt a search for an underlying cause. Contrast radiography should be used to evaluate the patient for underlying anatomical defects, urolithiasis or neoplasia. Cats with dilute urine are at higher risk for UTI. Metabolic diseases such as diabetes mellitus or chronic renal failure may also predispose the feline patient to bacterial UTI.
Diagnosis of bacterial UTI requires a urine culture. Therapy will be dictated by the results of culture and sensitivity testing. E. coli and gram-positive cocci are the most common isolates. Proteus, Klebsiella, Pasteurella, Enterobacter, and Pseudomonas are occasionally seen. Antibiotics are routinely prescribed for cats with FLUTD. In many cases this constitutes inappropriate therapy because the vast majority of FLUTD patients do NOT have bacterial UTI.

Miscellaneous Infectious Agents
Mycoplasma and Ureaplasma species have been suggested to play a role in FLUTD. However, there is currently no evidence that they act as primary pathogens.
Fungal urinary tract infections have been reported in cats, although they are rare. Fungal infections are also likely to result from impaired urinary tract defenses. The diagnosis is based on examination of urine sediment, but urine culture should be performed. Causes include Candida albicans and Aspergillus fumigatus. Fluconazole is the preferred therapy for candida infections.
Capillaria felis cati is a nematode parasite that has been associated with FLUTD.

Urethral Plugs, Urolithiasis, and Crystalluria
Although the urinary system is designed to dispose of wastes in liquid form, some components of urine may precipitate to form crystals. These crystals may be simply carried out of the urinary tract with the flow of urine; however, if they are retained, they may grow in size, or combine with organic matrix, to become large enough to be clinically significant.

Urethral Plugs
Plugs are objects of any composition that obstruct passageways or ducts. Feline urethral plugs are usually composed of large quantities of matrix (protein) mixed with minerals. Some urethral plugs are predominantly composed of matrix, some may contain tissue fragments, blood cells and cellular debris, and a few may be composed primarily of crystalline minerals. The description of urethral plugs should reflect their mineral and matrix composition, if known.
Minerals identified in feline urethral plugs include ammonium urate, calcium oxalate, calcium phosphate, and magnesium ammonium phosphate (struvite). Struvite plugs are the most common. Risk factors for the formation of these crystals in urethral plugs are probably similar to those associated with mineral formation in urolithiasis.
The components of feline urethral plug matrix have not been fully elucidated. One candidate is Tamm-Horsfall glycoprotein (THP), which is present in higher concentration in the urine of male cats with urethral plugs, compared to normal cats. THP has also been identified in human and ovine uroliths. THP is a 100 kD glycoprotein produced by the cells lining the thick ascending limb of the loop of Henle. It is the most abundant protein in normal human urine, however its function is unknown. It has been hypothesized to play a role in urine concentration, immunoregulation, and resistance to bacterial colonization of the urinary tract. Other non-crystalline components of feline urethral plugs include red and white blood cells, epithelial cells, spermatozoa, virus-like particles, and bacteria.
Osborne and coworkers have hypothesized that the formation of matrix-crystalline urethral plugs is the result of two concomitant, but etiologically distinct, disorders. These disorders are lower urinary tract inflammation (idiopathic or infectious) and crystalluria. Urinary tract inflammation alone may lead to accumulation of mucoprotein and inflammatory reactants which are readily voided through the urethra. Affected cats show signs of dysuria or hematuria, but urethral obstruction is unlikely. In the presence of conditions promoting crystal formation and growth, without inflammation, classical urolithiasis may result. The concomitant occurrence of urinary tract inflammation and crystalluria may lead to the formation of matrix-crystalline plugs (“fruit jello” hypothesis), which may lead to obstruction.

Urolithiasis
Urolithiasis accounts for approximately 20- 25% of cases presented for FLUTD. Uroliths are macroscopic polycrystalline concretions composed primarily of minerals (organic and inorganic crystalloids) and small amounts of matrix. They may be named according to location; e.g. nephrolith, urocystolith. (lithos = stone; sabulous = sand; calculus = pebble).
Over the last decade, there has been a significant change in the prevalence of struvite and calcium oxalate uroliths in cats (and dogs). This is at least partly due to the use of calculolytic diets to dissolve struvite uroliths, along with the use of modified maintenance and prevention diets. The latter have reduced the prevalence of struvite urolithiasis, while calcium oxalate uroliths have become considerably more common. Both magnesium restriction, and urine acidification, which are used to control struvite urolithiasis, may predispose cats to the development of calcium oxalate urolithiasis.
Struvite Urolithiasis
Struvite is magnesium ammonium phosphate hexahydrate. The majority (90%) of feline struvite uroliths are sterile, however a small percentage result from urinary tract infection with urease-producing bacteria (especially staphylococci). Struvite can also be a significant component of feline urethral matrix-mineral plugs.
Risk factors for struvite include dietary factors and possibly obesity. Initially, the ash content of diets was thought to influence the formation of struvite, however subsequent studies focused on the role of dietary magnesium. Cats fed diets with a high (0.45%) content of MgO developed struvite urolithiasis. However, MgO is an alkalinizing salt, and it was later demonstrated that a high magnesium (0.5%) diet in which the magnesium was present as MgCl2, did not result in the formation of struvite. MgCl2 is an acidifying salt and can therefore actually prevent struvite urolithiasis.
Sterile struvite uroliths can be medically dissolved by feeding a diet which promotes a urine pH of 6.3 or less, which is restricted in magnesium, and which is supplemented with NaCl. The latter stimulates thirst and promotes dieresis. There are some risks associated with the use of diets designed for dissolution of struvite. Chronic use of acidifying diets leads to metabolic acidosis, which can lead to decreased bone formation and detrimental effects on calcium, phosphorus, potassium, and magnesium balance. Potassium depletion, hypokalemia, and chronic renal failure can result from feeding acidifying diets which have a marginal potassium content. The use of acidifying diets is also contraindicated in cats with chronic renal failure as these animals are often already acidotic. The use of diets high in NaCl should also be avoided in animals with congestive cardiac failure. Finally, as indicated above, the use of diets designed to dissolve struvite may lead to a higher risk of calcium oxalate urolithiasis.
Infection-induced struvite uroliths should be managed with anti-microbials in addition to dietary therapy. Antibiotics should continue for as long as struvite uroliths are present, as microbes can persist in the inner layers of the uroliths, and are released as they dissolve.
Calcium Oxalate Urolithiasis
Risk factors include the use of acidifying diets. Magnesium restriction and NaCl supplementation may also play a role. Persians, Himalayan, and Burmese cats are over-represented. Hypercalcemia should always be ruled out in these patients.
Management is by surgical removal of large stones, if clinically indicated, or voiding urohydropropulsion of smaller stones. However, calcium oxalate uroliths are often clinically silent. If they are not causing lower urinary tract signs they may be left in place in the bladder; a risk of later obstruction, especially in male cats, persists. Strategies for prevention include feeding non-acidifying diets that are protein-restricted (lower in calcium and oxalic acid) and high in moisture.
Ammonium Urate Urolithiasis
These are usually idiopathic, however portovascular anomalies and a renal tubular defect have been implicated in some cases. Risk factors include a diet high in purine precursors (especially liver), highly acidic and highly concentrated urine. Preventive diets should therefore avoid these risk factors. Medical dissolution of urate uroliths has not been fully developed for the cat. Naturally occurring xanthine urolithiasis had also been reported in at least one cat.
Calcium Phosphate Urolithiasis
These account for approximately 1% of feline uroliths. Potential risk factors include hypercalciuria and hyperphosphaturia. There are no medical protocols for dissolution of these uroliths. Diets avoiding excessive protein, sodium, calcium, and vitamin D may be useful in reducing the risk of calcium phosphate urolithiasis. Increased water consumption may also be beneficial.
Cystine Urolithiasis
This results from aminoaciduria due to a tubular defect

Crystalluria
Crystals form in urine that is supersaturated with respect to crystallogenic substances. Therefore crystalluria is a risk factor for urolithiasis and the formation of matrix-mineral urethral plugs. Detection of crystalluria does not necessarily predict the formation of stones or the development of urethral plugs. Evaluation of crystals can be useful in detection of disorders predisposing to urolithiasis or plug formation (for example, cystine or ammonium urate crystals). It can also be used to estimate the composition of uroliths or plugs, and can be used to monitor the effectiveness of medical dissolution or prevention of urolithiasis. Frequent detection of large aggregates of crystals may also be significant It is important to remember that crystals can form, or dissolve, in urine after voiding.
There is no currently available evidence to suggest that crystalluria alone is a cause of FLUTD.

Miscellaneous Structural Causes
Other causes of FLUTD include congenital and hereditary defects, acquired anatomical defects, neoplasia, trauma, and iatrogenic disorders.

Idiopathic Feline Lower Urinary Tract Disease (Idiopathic Cystitis)
A recent prospective case series of 109 cats with nonobstructive urinary tract disease identified 70 cats (64%) which had stranguria, hematuria, pollakiuria or inappropriate urination with no evidence of anatomical defects, neoplasia, UTI, or urolithiasis. These cats had bladder lesions compatible with inflammation identified during radiographic or cystoscopic examination. Therefore, their clinical signs were attributed to idiopathic cystitis. Radiographic changes included diffuse or focal thickening of the bladder wall, or dissection of contrast into the bladder wall. All the cats examined by cystoscopy (21) had multiple submucosal petechial hemorrhages. Hematuria was present in 46% of the cats with idiopathic cystitis. Pyuria was rare (3%). In 20% of cats with idiopathic cystitis, inappropriate urination was the only clinical sign. These cats had no signs of hematuria, stranguria, or pollakiuria, and had normal urinalyses. These cats all had radiographic or cystoscopic abnormalities. Almost all the cats with idiopathic cystitis showed urination in inappropriate places. This case series showed a significant association between idiopathic cystitis and the feeding of a dry diet.
The natural history of IFLUTD is one of cyclic episodes of lower urinary tract signs lasting 3 days to 2 weeks (occasionally longer). The episodes of active clinical signs may be precipitated by stress. Most cats with IFLUTD develop the condition at a young age (2-3 yrs) and they will cease to have episodes in middle age. IFLUTD is not a steroid-responsive or antibiotic-responsive disease.
Viral Infections
For many years veterinarians have hunted for viral cause of IFLUTD. Viruses isolated from urine and tissues of cats with IFLUTD include BHV-4, FCV, and SFV. BHV-4 is bovine herpesvirus 4, which was initially termed CAHV (cell-associated herpesvirus). Members of this group are distinct from feline rhinotracheitis virus (FHV-1) and other bovine herpes viruses; they are able to replicate in a wide variety of experimental hosts. While there is some experimental evidence to suggest a role for BHV-4 in IFLUTD, strong clinical evidence has not been presented.
Feline syncytia-forming virus (SFV) has been isolated from cats with naturally occurring FLUTD, however there is no experimental evidence for a causal role for this virus. Feline calicivirus (FCV) has been suggested to cause FLUTD in experimental cats, but has not been isolated from naturally occurring cases.
There does not appear to be a significant relationship between FLUTD and seropositivity to FIV.
Interstitial Cystitis (IC)
Interstitial cystitis is a lower urinary tract disorder of humans that shows some similar features to FLUTD. This disorder is most common in women of 20 to 40 years of age; and it is characterized by difficult, painful, and frequent urination, with no discernable cause. The diagnosis of IC requires the presence of the appropriate symptoms, sterile and cytologically negative urine, and characteristic cystoscopic findings. These must be present without any other diagnosable cause. The characteristic cystoscopic findings are submucosal petechial hemorrhages (glomerulations) after hydrodistension of the bladder to 80 cm water pressure.
Comparison Between IC and IFLUTD (idiopathic cystitis)
Clearly the signs of dysuria, stranguria and pollakiuria are similar in IC and IFLUTD. In addition, the signs can be of variable severity, with a waxing and waning course, and the possibility of spontaneous remissions. In both IC and IFLUTD, the urine is sterile and cytologically unremarkable. Microscopic hematuria is more common in the feline disease, however this may be partly due to the frequent use of cystocentesis for urine collection in the cat. Radiography is more commonly used to evaluate cats for the presence of IFLUTD, as cystoscopy is less readily available. However, in the all the cats examined by cystoscopy in the Buffington study, lesions were seen that correspond to the glomerulations seen in human IC. These lesions have not been detected in normal cats.
Histopathology in human IC patients shows a relatively normal epithelium and muscularis, with submucosal edema, and vasodilation. Mast cells may also be present, but there is relatively little inflammatory infiltrate. Similar changes have been described in IFLUTD.
Increased sensory nerve fiber density occurs in the bladders of patients with IC. This suggests a role for neurogenic inflammation in the pathogenesis of IC. Substance-P containing nerve fibers are increased in the submucosa of some cats with IFLUTD, and some humans with IC. Bladder epithelial permeability is also increased in human and feline patients with IFLUTD. This could be an effect of substance-P.
One of the most consistent findings in human patients with IC is that the natural coating of glycosaminoglycans (GAGs) that lines the bladder uroepithelium is defective in some patients. A functional deficit in this protective layer exposes the underlying epithelium to the damaging effects of irritating urine components. A defect in the GAG layer may also be responsible for the increased bladder epithelial permeability seen in IC and IFLUTD. In both human patients with IC and IFLUTD, urinary GAG excretion is reduced, which has been attributed to increased binding of GAG to the urinary epithelium.
Although comparisons between IC and IFLUTD are fascinating, and may direct us towards new therapies for IFLUTD, it is important to bear in mind that these are both idiopathic disorders. Any similarities between the two disorders may be coincidental, or they may reflect the limited ways in which the lower urinary tract responds to a variety of insults.
Treatment of Feline Idiopathic Cystitis
The finding of a defective GAG layer in human patients with IC has lead to the use of a semi-synthetic mucopolysaccharide for treatment of this condition. Pentosan polysulfate sodium (ElmironÒ - Baker Norton) has been shown to be beneficial in relieving symptoms of IC. Pentosan is poorly absorbed from the GI tract, but 4-11% of the oral dose is excreted in the urine, where it is believed to act by adhering to the luminal aspect of the bladder mucosa, thus maintaining the permeability barrier. Pentosan is also effective when administered by the intravesicular route. It has been used in a limited number of cats with anecdotally good results. Clinical trials are ongoing.
Amitriptyline is potentially beneficial in the management of IFLUTD, for a number of reasons. This tricyclic antidepressant inhibits the reuptake of neurotransmitters, such as norepinephrine and serotonin, and has potent anticholinergic activity. In the management of IFLUTD, amitriptyline may act as an analgesic and a stabilizer of mast cell membranes. The anticholinergic effects may reduce frequency of urination. The dose for cats is 2.5 to 12.5 mg once daily. It is usual to start at the low end of the dose range, and increase if necessary because side effects are possible. The tablets taste extremely bitter and should be placed in gel-caps if possible. They can not be hidden in food. Mild sedation may be seen, and therefore cats are best dosed at night time. Controlled safety and efficacy studies are not available, therefore serum liver enzymes should be regularly evaluated in patients receiving amitriptyline.
Dietary management was previously considered important for the prevention of episodes of IFLUTD. This now appears to be of questionable benefit. Acidifying diets to minimize the formation of struvite crystals may reduce the risk of obstruction in male cats with IFLUTD. Some people have theorized that an acid urine might irritate the inflammed bladder wall and lengthen episodes of IFLUTD.
Antibiotics and corticosteroids are not useful in the management of IFLUTD. As this disorder can go into spontaneous remission, some “cures” are falsely attributed to medical therapy. Propantheline bromide can be considered for cats with severe detrusor hypercontractility. The dose is 7.5 mg once. The tablets are extremely bitter and can be placed in gel caps.
Other useful management strategies include minimizing stress and feeding a diet with a high water content. Stress is highly significant in inducing a “flare” of symptoms in human IC. Similarly in cats, signs of FLUTD often follow severe weather or climatic changes, or other stressors such departure of an owner, moving to a new home, or other changes in the household. Stress in cats may be reduced by providing places to hide, and opportunities to climb, play, and “hunt”.

Evaluation of the Feline Patient with Signs of Lower Urinary Tract Disease
Urinalysis
If the urine sample can not be evaluated immediately, it should be refrigerated.
pH can be affected by a recent meal, and by stress. A stressed cat may hyperventilate, leading to alkalosis and urinary alkalinization.
Hematuria may be induced by cystocentesis.
Crystals can form, or dissolve, after voiding.
Culture is necessary to document bacterial UTI.
Imaging
Plain and contrast radiographs
Ultrasound
Cystoscopy: can be difficult in the male cat.
The results of the Buffington study indicate that imaging of the lower urinary tract is necessary to rule out IFLUTD, before signs of inappropriate urination can be attributed to behavioral disorders.
Biochemistry and Hematology
These may be useful in addressing underlying diseases, such as causes of hypercalcemia, diabetes mellitus, and liver disease.
Stone or Plug Analysis
Stones and urethral plugs should always be submitted for analysis, so that preventive measures can be introduced, if possible. Methods of analysis can be qualitative or quantitative. The latter is strongly preferred, and includes optical crystallography, infrared spectroscopy, and x-ray diffraction. Qualitative testing uses chemical tests to identify chemical radicals and ions, and is not recommended.



note: much of the content of this handout was provided by Katharine Lunn




Bibliography

Consultations in Feline Internal Medicine (3) (August) Chapters 46 (Osborne et al) and 47 (Buffington and Chew).

Veterinary Clinics of North America: Small Animal Practice 26 (2) and (3). Disorders of the Feline Lower Urinary Tract I and II. March and May, 1996.

Osborne et al., JAVMA 196 (7) 1053-1063, 1990. Medical dissolution of feline struvite urocystoliths.

Buffington, J. Nutrition 124 2643S-2651S, 1994. Lower urinary tract disease in cats - new problems, new paradigms.

Buffington et al., JAVMA 205 (11) 1524-1527, 1994. Lower urinary tract disease in cats: Is diet still a cause?

Buffington et al., JAVMA 210 (1) 46-50, 1997. Clinical evaluation of cats with nonobstructive urinary tract diseases.

Hanno, Urology 49 (Suppl 5A) 93-99, 1997. Analysis of long term Elmiron therapy for interstitial cystitis.

[C.C.'s Mom]

Oh no! That sounds terrible! Whatever you decide Randi, we'll be thinking of you and Fister.

[Randi]

Thanks SAS for the article - heavy reading for a non english! Still waiting for the vet to call back, he's busy today. :(

Thanks Brigitte! :)

[sasvermont]

Feline Urinary Syndrome (FUS)
Feline urinary syndrome or FUS is the name given to a group of symptoms that occur in the cat secondary to inflammation, irritation, and/or obstruction of the lower urinary tract (urinary bladder, urethra, and penile urethra). A cat with FUS can exhibit one, some, or even all of the symptoms.
FUS is NOT a specific diagnosis: there are many known and some unknown factors that may cause or contribute to FUS. Any cause resulting in particulate debris in the urine is capable of causing obstruction in the male cat.

Males are much more likely to get this disease than females. There is no known means of prevention. Treatment can vary from diet to surgery. Cats usually recover if the disease is caught in time; often the cat must be watched for any recurrence of FUS.

Symptoms
May appear periodically during the life of the cat.

Females: straining to urinate, blood in the urine, frequent trips to the litter box with only small amounts voided, loss of litterbox habits.

Males: In addition to the above symptoms, small particles may lodge in the male urethra and cause complete obstruction with the inability to pass urine-this is a life and death situation if not treated quickly.
Obstruction usually occurs in the male cat and is most often confined to the site where the urethra narrows as it enters the bulbourethral gland and penis; small particles that can easily pass out of the bladder and transverse the urethra congregate at the bottleneck of the penile urethra to cause complete blockage. (note that the female urethra opens widely into the vagina with no bottleneck).
Symptoms of obstruction are much more intense than those of bladder inflammation alone; this is an emergency requiring immediate steps to relieve the obstruction. Symptoms include:

Frequent non-producing straining-no urine produced, discomfort, pain, howling.
Gentle feeling of the cats abdomen reveals a tennis ball size structure which is the overdistended urinary bladder.
Subsequent depression, vomiting and/or diarrhea, dehydration, loss of appetite, uremic poisoning, and coma may develop rapidly within 24 hours.
Death results from uremic poisoning; advanced uremic poisoning may not be reversible even with relief of the obstruction and intensive care. Bladders can be permanently damaged as a result.
Causes of FUS
In general: any condition that causes stricture, malfunction, inflammation, or obstruction of the urethra. In addition, any condition that causes inflammation, malfunction, or abnormal anatomy of the urinary bladder.
Known causes
Struvite crystals accompanied by red blood cells-generally caused by a diet too high in magnesium relative to the pH of the urine.
Fish-flavored foods tend to be worse
The ability of a given diet to cause problems in an individual cat is highly variable: only those cats with a history of this kind of FUS may respond well to strictly dietary management. Many cats do not have problems with a diet that may produce FUS in some individuals.
Bladder stones, may occur from struvite crystals, or be secondary to bladder infections. There are metabolic disorders (not all are understood) that result in a higher concentration of a given mineral that can remain in solution; hence stones are formed. Diet may greatly modify the concentration of a given mineral in solution in the urine. Water intake may modify the concentration of all minerals in the urine, and bacterial infection increases the risk of stone formation.
Anatomical abnormalities such as congenital malformations of the bladder and/or urethra (early neutering is NOT a factor) OR acquired strictures of the urethra and/or scarring of the bladder.
Trauma.
Neurolgenic problems affecting the act of urination (difficult to diagnose except at institutions capable of urethral pressure profiles)
Primary bacterial infection-RARE!
Tumors (benign/malignant)
Protein matrix plug (generally urethral obstruction of males); can be from non-mineral protein debris, viral-based, other causes are unknown.
Suspected or unknown factors include non-bacterial infections, toxins, stress, and seasonal influences.
Management of FUS
Obstruction of the male cat is a medical emergency. The obstruction must be relieved immediately.
Failure to produce a good stream of urine after relief of obstruction is indicative of urethral stricture and/or stones or matrex plugs. Failure of bladder to empty after relief of obstruction suggests bladder paralysis (usually temporary unless present prior to obstruction). In either event, a urinary catheter must be placed to allow continual urination.

Treatment of uremic poisoning requires IV fluid therapy with monitoring of blood levels of waste products until uremia is no longer present.

Permanent urethral damage with stricture, inability to dislodge a urethral obstruction, or inability to prevent recurring obstructions are all indications for perineal urethrostomy (amputation of the penis and narrow portion of the urethra to create a female-sized opening for urination). This procedure is usually effective in preventing reobstruction of the male cat, but this procedure should be a last resort

If FUS is indicated without obstruction, 75 to 80% of FUS cats without obstruction may be sucessfully managed by diet alone if urine reveals typical crystals and red blood cells. Unobstructed male cats or non-uremic obstructed males who have a good urine stream and bladder function after relief of an early obstruction may be managed as above initially. Cats who are symptom-free after 7 to 10 days of dietary management and who have normal follow-up urines at 21 days, may be maintained indefinitely with dietary management only.

DL-Methionine is often prescribed for cats with FUS. Most commonly, FUS-specific diets contain this acidifier. Antibiotics may be used. Distilled water for FUS-prone cats is often recommended as well.

[sasvermont]

http://www.healthypet.com/Library/cat_dog_health-17.html

rather than print the whole thing, just cut and paste this into your explorer

how's it going? has he been able to use the potty?

[Randi]

Thanks again SAS! That was a very good article on the problem!

Fister has made a tiny puddle outside his box and is now sleeping in the chair. He has been under the bed a few times today, which is not normal, he usually sleep ON it! He is not complaining loudly yet, but I'm sure he will later. John spoke to the vet while I was out and wanted me to ring back, but I haven't been able to get hold of him yet! :mad: He wants to know what food he's had lately and said that it was best to change betweeen the dissolving diet food and the preventive. He's only had the dissolving. It looks like we'll have to wait till tomorrow, hopefully he has time then!!

Will keep you updated! :)

[sasvermont]

http://petplace.netscape.com/netscape/nsArtShow.asp?artID=3363

[momoffuzzyfaces]

Poor Fister!
They make dry food that is specially for helping prevent UTI. Have you tried them? My vet said neutered males are more prone to UTI than ones who are not neutered. 3 of my boys had problems for a while until I put them on a food for UTI prevention. I can't remember the name right now. They eat a hairball control one now and have not had any problems with UTI on it. You could ask the vet about it. Fingers and Paws all crossed for poor Fister to get to feeling better soon.

[zippy-kat]

Oh poor Fister!! You and Phred's Boots-Cat should start a support group.

Get well soon dear orange one!

[Randi]

Thanks for the article - it's very good!

Lut! Yes, it's definately nice to get more than one vets opinion, especially if they agree!! :)

Our vet just rang back. He will of course take Fister tomorrow if neccesary. He also said that he didn't think Fister needed to be operated. Phew!! However, he will ring the vet hospital and ask why they think it's necessary. He knows a few of them already. As I said to him, I don't like two vets have different opinions and he agreed!

So, I'll call him tomorrow morning and report how Fister is doing. I'm pretty sure he'll be flushed through again and a cahteter put up.

Thanks for all your support! :)

[Former User]

Randi, I'm so sorry to hear Fister has problems again, poor baby!
Looking forward how it goes tomorrow, I hope nothing serious will happen during the evening/night.
Thanx for keeping us posted!

Headbumpies to Fister from Casper and Kitty :)

[tatsxxx11]

Randi, I'm so sorry to hear about Fister's setback:( Fister and poor Boots seem to be in the same boat! We'll be anxiously awaiting the vet's call! Poor Fister. Geez, that one option does seem drastic! I'm sure my human patients are relieved to know that's not an option for human UTI's! I'm sure after some consultation, you'll do what's best for dear Fister. Oliver and Mr. B send him headbumpies and pawpats. And hugs and kisses from me!

[krazyaboutkatz]

I'm so sorry to here about Fister's ongoing problem. I have three neutered male cats and so far they haven't had this problem. They are also indoor only cats. I hope everything goes well. Paws and fingers are crossed here. Please keep us posted. Good luck.

[lynnestankard]

Oh Randi - poor Fister. Hope things are going to be better today. Let us know how the lovely boy goes on won't you?

Lynne

[Randi]

Had a chat with the vet this morning and he doesn't think Fister need any treatment yet, but then he's had a pee this morning - in his box (the amount of a broken eggyolk, which the vet thought was enough), so hopefully he'll continue feeling better! I'm keeping him on Hills diet food s/d and I'll put it out 2-3 times a day, a little at a time. This should also help keep the balance. And I'll try and get him to drink as much as possible too.

If he gets problems later today, the option is to take a sample of his pee (if i can get any) and have it analyzed - and I can come over with him if neccesary.

My vet is taking a vaccation for one week now, but his secretary can get hold of him.

Since he's so busy and I don't have a job at the moment, I offered to come over and help him out now and again - he said he might just take me up on that!

Thanks for your support and concern! Your good vibes toward Fister seem to have helped! ;) But keep your fingers crossed! :D

[Former User]

Keeping our fingers crossed, and Casper and Kitty just crossed their paws for Fister. Hope you feel well soon buddy! Make mommy happy and have a really nice long pee, ok? ;)

[sasvermont]

Randi, you may want to try to give Fister eye droppers filled with water. I did that with one cat, and she rather liked being 'waited on' .... I got much more water into that way. I would sit her on my lap, put the dropper in the corner of her mouth and let it rip. She would drink it... thinking it was fun. It got her through a very tough time, when she was unable to drink by herself.

Can't hurt to give it a try.

Keep us posted on Fisters....well, kitty box habits....

SAS

[momoffuzzyfaces]

Originally posted by sasvermont
Randi, you may want to try to give Fister eye droppers filled with water. I did that with one cat, and she rather liked being 'waited on' .... I got much more water into that way. I would sit her on my lap, put the dropper in the corner of her mouth and let it rip. She would drink it... thinking it was fun. It got her through a very tough time, when she was unable to drink by herself. SAS SAS this reminded me of a cat I had that loved drinking straws. I was able to give her liquid by putting the straw in water (or whatever) and holding my finger over one end. When she started to chew on the other end, I took my finger off. She loved it.:)

[Randi]

I don't really know what these eyedroppers are. :o ... but then, Fister is drinking more or less as usual (1 dl a day), the vet says: That's OK! But I do encourage him to drink more, so today I filled a syringe with water (15 ml.) and sprayed slowly in his mouth. He's not TOO keen on it, but if I'm patient I can get some most off it in. Ohh, you should see him when I try that, he looks really funny - hasn't got a clue what it's all about - at least he's not attacking me! :D I can do this while he's sitting in the windowsill - he's not a labcat, but he WILL lay across John's chest in bed whenever possible and share my pillow when he thinks I'm asleep! :D

I do think he's feeling better today, so I'll keep watching him carefully and report his next trip to the box! ;)

By the way, how often does your cat pee?? :rolleyes:

[Edwina's Secretary]

Randi -- Edwina pees usually twice a day. (More only if she is showing off for visitors.)

I am so concerned for Fister. He is a favorite of mine. The story of him working his way into your bed (:eek: :eek: ) is one I shared with my husband. It reminded me so of my Edwina!

[sasvermont]

My "computer wallpaper" at home is Fister's pic.....the one with his long tongue out. I do like him so and have enjoyed all the funny stories and tales about him.

Eye dropper... is similar to a syringe.... they can be found in nose drop medications... and sometimes used to give children their liquid medication. Anything that holds water and is small enough to fit in the cat's mouth will work. Even a straw, as stated above.

I really believe the key to this is water, water, water.

[tatsxxx11]

Hi Randi. I was so relieved to hear that Fister is improving. And I agree with SAS that an adequate fluid intake is SO important for good urinary health. I will he keeping positive thoughts that our darling Fister will continue to improve! Hugs to Fister from Sandra, Mr. B and Oliver!

[NoahsMommy]

Poor little guy! I hope things get better for that little orange sweetie! Let us know how things are going for him...he'll be in my prayers...

[Sara luvs her Tinky]

Poor Fister :(
I hope you are feeling better soon poor kitty.....:(

[Former User]

Randi, how is Fister-boy doing?

I haven't got a glue how many times Casper and Kitty pee, haven't really paid attention :rolleyes:

[Randi]

Thanks for thinking of Fister! :) He is doing much better, he's more sociable and doesn't sleep under the wardrobe or under the bed in the daytime now, although I don't think he drinks quite enough. Well, we try and encourage him to drink more, even if it means that we have to come to the bathroom and pour water across the floor. :D That's how he wants it in the afternoon. :rolleyes:

He pees 2 times in 24 hours, I guess that's all right!

Will post a recent picture tomorrow! ;)

[Heather Wallace]

Randi, I do hope that fister is a little better now. Keep us updated on his progress and what the vets say.

[Former User]

Randi, I'm glad he's more or less back to normal. Sounds funny how he likes his water in the afternoon, but hey, anything to please these furkids, right ;)

[sirocco]

As you know, Randi, I missed this thread :( But you see that now I regularly check it ;) ;) !!

I'm very happy to hear that Fister is doing right now!! Keep on the good work - you surely are doing a very very good job trying to make him drink water - quite a deal, too!

Headbumpies and purrs for Fister! Hurrah!!! :D :D :D

Un abrazo,
Nita

[sasvermont]

Randi, I am so glad to her that your furry friend Fister is doing much better. Since your posting this message, I have put out many small bowls of water around the house, including the porch. The cats are curious and sometimes drink from them at the funniest of times. They need as much water as possible! They love drinking from MY glass, so I often leave full cups of water on table tops... (I hear your minds going a mile a minute, thinking, wow, she must live in a real exciting dump....with lots of buckets of water sitting around....hehehehehe) Actually, I have very attractive bowls, sorta tucked in corners and away from the foot traffic. No one would notice. I bet I have about 6 bowls for 3 cats....and then a couple of cups. WATER - WATER - WATER...

[krazyaboutkatz]

I'm so glad that Fister is doing better. Hopefully he'll get back to normal very soon and stay that way. Please keep us posted.http://www.gifs.net/animate/aflower6.gif

[yorkster]

Oh Randi! I'm so sorry I missed this thread until today :(
I do hope that Fister is doing/feeling better. :) I had a male cat sometime ago that had some problems with this, however not as bad. The Science Diet Prescription food was all that he could eat, and NOTHING else (not even treats :( )

I also heard somewhere that a little apple-cidar vinegar in the water helps (I would check on that before you try anything at this time, since he is so sick) I know the vinegar is quite good for us people for so many things including urinary tract.

Let us know how it goes, and I will be thinking of you and sweet Fister!

[yorkster]

Randi, I just tried to PM you and your mailbox is too full to accept anymore. :(
How is Fister doing?

[AmberLee]

Yoowww!!! Fister, ol' bud, ol' pal!!!! I had no idea you were so sick while I was at the cat spa. How ya doing now bud? Are your human parents still looking at ya funny with the scissors? Be VERY careful, guy. Report back when your mommy isn't watching: I'm very worried about you.

Cassy >^._.^< :eek:

[lovemymaltese]

I'll be thinking of Fister.

[Randi]

Cassy, it's Fister here. Thanks for your concern, I escaped the scissors this time, though. Thought it would be best for all parts to go and have a pee in the box, and I've have been very good since! My humans get so upset and nerveus when I play this trick on them.

Then yesterday, my humans had dinner guests, I hate that because they get so busy with all kinds of unimportant things and tend to forget about me a bit! And the boring conversations they have! OH my!! They did offer me to go out in the yard, but I wouldn't, because that nasty new male cat Ib was also out there. :mad: Instead I took a looong nap in the bathroom. Because of all of this, I thought I'd give them another scare today and haven't peed since yesterday. It's best to choose a saturday morning, because the vet are closed during weekends and I can get my humans to cuddle me and spoil me even more! ;)

Well, lets see how I'm doing in a few days - will let you know!

Purrs and headbumpies to you and Livvy! Give your mum a few too - but don't touch her eyes! .... and tell her we're all very glad to see her back here at PT! :D

[yorkster]

Fister, you naughty kitty! :p
Hope you are better today (any pee-pee?)

[Randi]

Yes Yorkster! I peed today - and yesterday!! My humans let me out in the backyard yesterday evening, I had such fun rolling around in the grass and checking everything out under bushes and in the flower beds. Great time! :D

Randi here! Fister forgot to tell how naughty he was! He wouldn't come up again, so at 23.00 PM I went down to look for him and he sat on a table watching every little movement. He let me stroke him, but when I said: Are you coming up now? he growled at me!! Then an hour later (I was definately ready for bed!) I shook the dry food container and he came running. Down the stairs again, but he hasn't finished looking around yet - might still be something interesting :rolleyes: , so I lost my patience and put something in the door and went back up. 10 min. later, there he was, in the middle of the living room. So, time to rush to the kitchen and close the door!! :rolleyes:

[sirocco]

Hi, Fister! Sirocco here! :D I admire you sooo much, I've been reading your coming and goings when Nita left the PC unattended... hehe, and I'm a good pupil - I've invented a Spanish version of your wanderings. We don't have backyards here... but I've discovered the FLAT ROOF - all Triana roofs are under my feet now ;) I know how to meow in the most pitiful way to make her open the door to the flat roof and let me spend some time inspecting the surroundings!!! It is very funny: the other night I spent an hour looking at the moon from a chimney near my house and Nita was standing there so close, but she couldn't reach me, calling my name to make me go back, jeje :D Very funny indeed!

Headbumpies from your pal,
Siro

[sirocco]

Originally posted by Randi
10 min. later, there he was, in the middle of the living room. So, time to rush to the kitchen and close the door!! :rolleyes:

Nita here... oh Randi, I know that too well - Now that Siro loves going up to the flat roof (which is a nightmare for I can't prevent the rest of my neighbours to go there and open the door when they have to hang the washing out! and now Sirocco recognizes the sound the door makes when opening and there he goes in his very own fast and sneaky fashion :mad: :rolleyes: ) I have to be always on the alert! And when I see him back, I rush to the stairs to close the door!! (It's quite tiring too, being up and down the stairs all the time :eek: )

Mmm, very funny indeed (!?) ;)

Nita

[toughCookie]

It's best to choose a saturday morning, because the vet are closed during weekends

yes, aren't the kitties GOOD at doing that?:eek:

[Randi]

Hola Sirocco! Fister here. ;) I'm glad to hear you've invented a spanish version and have found a good place to go! Us cats we need a bit of fresh air and exercise now and again, so I can definately relate! It must be quite a good view you have from the rooftops of Triana - I'm a bit envious! ;) How I would love to sit there with you and look at the moon, it's so romantic! - but I have to remind you to be careful up there, don't go too close to the edge, it's probably a long way down and you can hurt yourself! :(

Ps. Have you met any other cats up there? I hope not!! :p

So you take care! :D

Lots of headbumpies and purrs from you pal,
Fister :cool:

[redc1983]

The week of Christmas my dog became sick and I had to keep her at the vet with iv's, they tried everything but her kidneys were failing. She just turned a year old 2 day before I had to put her to sleep. That was the hardest thing I had to do. She was my best friend. Now 4 months later my cat is sick. I took him to the vet. The vet says he has a renal obstruction and it sounds almost like the exact thing my dog had. I just feel it is strange that both have the same problems. Could it be that possible that something at my house is causing this. Please help. He is at the vet on iv's and not sure if there is going to be any hope. If anybody knows of there could be a link please let me know.

[Barbara]

RedC- I have no idea how you managed to add your question to that old Fister thread because many people won't find it here.

There IS hope- you can learn that from the thread.

The blockage can be caused by many things. As soon as it occurs you have to take the cat to the vet as a blockage can be life threatening.

If it is a so called idiopathic Urinary Tract Infection, cortisone might help. My Tigris had that one and a half year ago, he got antibiotics and cortisone and was soon ok- and has stayed ok :)

If it is crystals, a diet may help. If it does not help, there is surgery like the one Fister had (but I think it was not 2002, rather later).

Cats are prone to UTIs unfortunately. It will be nothing in your house that caused it.

Hope your kitty is well again.

[Tubby & Peanut's Mom]

Wow, way to give me a heart attack! I thought something serious had happened with Fister overnight while I wasn't on the computer. Whew! Thank goodness it's an old thread and all is still well with our favorite orangie boy. :D

rdc, sure hope all turned out well with your kitty. Can we have an uppydate please? :)

[lizbud]

Wow, way to give me a heart attack! I thought something serious had happened with Fister overnight while I wasn't on the computer. Whew! Thank goodness it's an old thread and all is still well with our favorite orangie boy. :D





Me too. :D I thought oh, no. :(